Structural insight into the bifunctional mechanism of the glycogen-debranching enzyme TreX from the archaeon Sulfolobus solfataricus.

doi:10.1074/jbc.M802560200

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Article

Structural insight into the bifunctional mechanism of the glycogen-debranching enzyme TreX from the archaeon Sulfolobus solfataricus.

The Journal of biological chemistry - 17 Oct 2008

Woo Eui-Jeon, Lee Seungjae, Cha Hyunju, Park Jong-Tae, Yoon Sei-Mee, Song Hyung-Nam, Park Kwan-Hwa

Abstract excerpt

TreX is an archaeal glycogen-debranching enzyme that exists in two oligomeric states in solution, as a dimer and tetramer. Unlike its homologs, TreX from Sulfolobus solfataricus shows dual activities for alpha-1,4-transferase and alpha-1,6-glucosidase. To understand this bifunctional mechanism, we determined the crystal structure of TreX in complex with an acarbose ligand. The acarbose intermediate was covalently...

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PMID: 18703518
DOI: 10.1074/jbc.M802560200
PMCID: PMC2661413

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.