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Article

Drug-resistant phosphatidylinositol 3-kinase: guidance for the preemptive strike.

Cancer cell - 12 Aug 2008

Vogt Peter K

Abstract excerpt

In this issue of Cancer Cell, Zunder et al. (2008) describe surprising findings from investigating inhibitor-resistant mutations in the affinity pocket of p110 alpha of phosphatidylinositol 3-kinase (PI3K). Information on these critical residues provides a road map for generating novel PI3K inhibitors that can overcome the anticipated resistance mutations.

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Share to Class I Phosphatidylinositol 3-Kinases
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Source

Identifiers

PMID: 18691545
DOI: 10.1016/j.ccr.2008.07.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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