Article
Preimplantation HLA haplotyping using tri-, tetra-, and pentanucleotide short tandem repeats for HLA matching.
Journal of assisted reproduction and genetics - 1 Jul 2008
Bick Sarah L, Bick David P, Wells Brent E, Roesler Mark R, Strawn Estil Y, Lau Eduardo C
Abstract excerpt
PURPOSE: To aid couples wishing to conceive children who are HLA matched to a sibling in need of a hematopoietic progenitor cell transplant, we developed a preimplantation HLA haplotype analysis of embryos that utilizes tri-, tetra-, and pentanucleotide STR markers. METHODS: For preimplantation HLA genotyping, we use polymorphic STR markers located across the HLA and flanking regions, selecting exclusively tri-,...
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