Cancer genetics: a primer for surgeons.

doi:10.1016/j.suc.2008.04.011

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Article

Cancer genetics: a primer for surgeons.

The Surgical clinics of North America - 1 Aug 2008

Benson John R, Liau Siong-Seng

Abstract excerpt

Contemporary ideas of carcinogenesis envisage a series of stochastic genetic changes that confer a selective growth advantage over healthy cells. These changes collectively lead to the disruption of coordinated networks of intercellular communication and cause a fundamental change in cellular behavior, which affects processes, such as proliferation, differentiation, and apoptosis. This progressive dysregulation...

Topics

Biomarkers, Tumor
Genes, Neoplasm
Genetic Predisposition to Disease
Humans
Neoplasms

Source

Open in PubMed

Identifiers

PMID: 18672136
DOI: 10.1016/j.suc.2008.04.011

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