Article
Novel EDA mutation resulting in X-linked non-syndromic hypodontia and the pattern of EDA-associated isolated tooth agenesis.
European journal of medical genetics - 1 Jan 2000
Han Dong, Gong Yu, Wu Hua, Zhang Xiaoxia, Yan Ming, Wang Xiaozhu, Qu Hong, Feng Hailan, Song Shujuan
Abstract excerpt
Familial non-syndromic hypodontia shows a wide phenotypic heterogeneity and inherits in an autosomal-dominant, autosomal-recessive or X-linked mode. Mutations in genes PAX9, MSX1 and AXIN2 have been determined to be associated with autosomal-dominant tooth agenesis. Recent studies in two families showed that X-linked non-syndromic hypodontia resulted from EDA mutations. In this study, a novel EDA mutation...
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