Article
The histopathology of BRAF-V600E-mutated lung adenocarcinoma.
The American journal of surgical pathology - 1 Sept 2008
Yousem Samuel A, Nikiforova Marina, Nikiforov Yuri
Abstract excerpt
BRAF mutations in lung adenocarcinoma are much less common than the more frequently reported and mutually exclusive mutations of KRAS and EGFR genes, and the clinical and histologic phenotype of BRAF adenocarcinomas has not been described. We analyzed 222 adenocarcinomas of lung lacking KRAS and EGFR mutations and identified 10 adenocarcinomas with BRAF-V600E mutation. All BRAF-V600E mutations were heterozygous....
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