Article
No association between polymorphisms in the FACL4 (fatty acid-CoA ligase 4) gene and nonspecific mental retardation in Qin-Ba mountain region of China.
Neuroscience letters - 22 Aug 2008
An Caiyan, Zhang Kejin, Gao Xiaocai, Zheng Zijian, Shi Zhenbao, Gong Pingyuan, Guo Yale, Huang Shaoping, Zhang Fuchang
Abstract excerpt
Mental retardation (MR) is a common form of cognitive impairment among children. The underlying causes of mental retardation are extremely heterogeneous and include significant genetic factors. Long chain fatty acid-CoA ligase 4 is the first gene shown to be involved in mental retardation and fatty-acid metabolism. FACL4 gene mutations in three Italian MR pedigrees have been reported as causing non-specific...
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