Article
Susceptibility to glaucoma: differential comparison of the astrocyte transcriptome from glaucomatous African American and Caucasian American donors.
Genome biology - 1 Jan 2008
Lukas Thomas J, Miao Haixi, Chen Lin, Riordan Sean M, Li Wenjun, Crabb Andrea M, Wise Alexandria, Du Pan, Lin Simon M, Hernandez M Rosario
Abstract excerpt
BACKGROUND: Epidemiological and genetic studies indicate that ethnic/genetic background plays an important role in susceptibility to primary open angle glaucoma (POAG). POAG is more prevalent among the African-descent population compared to the Caucasian population. Damage in POAG occurs at the level of the optic nerve head (ONH) and is mediated by astrocytes. Here we investigated differences in gene expression...
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