Article
Phenotypic heterogeneity in the Gray platelet syndrome extends to the expression of TREM family member, TLT-1.
Thrombosis and haemostasis - 1 Jul 2008
Nurden Alan T, Nurden Paquita, Bermejo Emilsé, Combrié Robert, McVicar Daniel W, Washington A Valance
Abstract excerpt
The Gray platelet syndrome (GPS) is a rare inherited disorder linked to undefined molecular abnormalities that prevent the formation and maturation of alpha-granules. Here, we report studies on two patients from unrelated families that confirm phenotypic heterogeneity in the disease. First we used immunoelectron microscopy (I-EM) to confirm that TREM-like transcript-1 (TLT-1) is mostly localized to alpha-granule...
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