Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Genetics factors determining predisposition to chronic course of virus hepatitis and fibrosis in liver].

Molekuliarnaia biologiia - 1 Jan 2000

Goncharova I A, Beloborodova E V, Freĭdin M B, Beloborodova E I, Chernogoriuk G E, Puzyrev V P

Abstract excerpt

Polymorphic variants of several genes IL4 C(-590)T, IL4RA Ile50Val, TNF G(-308)A were studied for their association with extent of the disease chronization which is marked by hepatic fibrosis stage. Gradual decrease in A allele frequency of polymorphic marker G(-308)A in TNF gene, from patients with weak fibrosis to patients with cirrhosis. Group of patients with weak fibrosis was characterized by higher...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Gene Frequency
Share to Hepatitis B, Chronic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis C, Chronic

Share to Interleukin-4

Share to Interleukin-4 Receptor alpha Subunit

Share to Liver Cirrhosis

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 18610831

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Genetics factors determining predisposition to chronic course of virus hepatitis and fibrosis in liver].PMID 18610831Read ↗

[Association of immune system gene polymorphisms with quantitative features which are pathogenetically important in chronic viral hepatitis].Semantic proximity Read ↗

[Association study of the Ile50Val polymorphism of interleukin-4 receptor gene (IL4RA) with chronic viral hepatitis].Semantic proximity Read ↗

[Mathematic Model for Prediction of Liver Fibrosis Progression Rate in Patients with Chronic Hepatitis C Based on Combination of Genomic Markers].Semantic proximity Read ↗

[MODEL FOR PREDICTING THE PROGRESSION OF LIVER FIBROSIS BASED ON BIOCHEMICAL AND GENETIC CRITERIA IN PATIENTS WITH CHRONIC HEPATITIS C].Semantic proximity Read ↗

[Alleles distribution of polymorphic promoter region C-590T in interleukin-4 genes and Q-576r and Ile-50Val regions in IL-4 receptor gene IL-4RA in patients with HCV-infection].Semantic proximity Read ↗

[Investigation of the association between chronic hepatitis B and C infections and TNF-α (-308) gene polymorphism].Semantic proximity Read ↗

[Genetic markers of predisposition to an aggressive course of chronic C hepatitis].Semantic proximity Read ↗

Influence of transforming growth factor-β1 and tumor necrosis factor-α genes polymorphisms on the development of cirrhosis and hepatocellular carcinoma in chronic hepatitis C patients.Semantic proximity Read ↗

A Meta-Analysis of the Influence of Tumor Necrosis Factor-α-308 Gene Polymorphism on Liver Cirrhosis.Semantic proximity Read ↗

The Synergistic Effect of TNFα -308 G/A and TGFβ1 -509 C/T Polymorphisms on Hepatic Fibrosis Progression in Hepatitis C Virus Genotype 4 Patients.Semantic proximity Read ↗

[THE INFLUENCE OF TUMOR NECROSIS FACTOR ALPHA AND POLYMORPHISM OF ITS GENE (RS1800629) ON THE SEVERITY AND PROGRESSION OF CHRONIC HEPATITIS AND ULCERATIVE COLITIS].Semantic proximity Read ↗

Impact of IL-27p28 (rs153109) and TNF-α (rs1800629) Genetic Polymorphisms on the Progression of HCV Infection in Egyptian Patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.