Article
Proportionality between variances in gene expression induced by noise and mutation: consequence of evolutionary robustness.
BMC evolutionary biology - 26 Jan 2011
Kaneko Kunihiko
Abstract excerpt
BACKGROUND: Characterization of robustness and plasticity of phenotypes is a basic issue in evolutionary and developmental biology. The robustness and plasticity are concerned with changeability of a biological system against external perturbations. The perturbations are either genetic, i.e., due to mutations in genes in the population, or epigenetic, i.e., due to noise during development or environmental...
Topics
- Biological Evolution
- Epigenomics
- Gene Expression
- Gene Regulatory Networks
- Genetic Fitness
- Genotype
- Models, Genetic
- Mutation
- Phenotype
- Selection, Genetic