Article
Early transplantation of human immature dental pulp stem cells from baby teeth to golden retriever muscular dystrophy (GRMD) dogs: Local or systemic?
Journal of translational medicine - 3 Jul 2008
Kerkis Irina, Ambrosio Carlos E, Kerkis Alexandre, Martins Daniele S, Zucconi Eder, Fonseca Simone A S, Cabral Rosa M, Maranduba Carlos M C, Gaiad Thais P, Morini Adriana C, Vieira Natassia M, Brolio Marina P, Sant'Anna Osvaldo A, Miglino Maria A, Zatz Mayana
Abstract excerpt
BACKGROUND: The golden retriever muscular dystrophy (GRMD) dogs represent the best available animal model for therapeutic trials aiming at the future treatment of human Duchenne muscular dystrophy (DMD). We have obtained a rare litter of six GRMD dogs (3 males and 3 females) born from an affected male and a carrier female which were submitted to a therapeutic trial with adult human stem cells to investigate their...
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