Article
[Association of gene polymorphisms of CYP1B1 with intrahepatic cholestasis of pregnancy].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition - 1 May 2008
Wang Xiao-Li, Tan Xin, Zhang Lia, Ou Rong-Ging, Yan Ai-Hua, Chen Qiang, Zou Hai
Abstract excerpt
OBJECTIVE: To study the role of gene polymorphisms of cytochrome P4501B1 (CYP1B1) in exon 2 codon 119(G-T) and exon 3 codon 432(C-G) in intrahepatic cholestasis of pregnancy (ICP). METHODS: Gene polymorphisms of CYP1B1 in exon 2 codon 119 and exon 3 codon 432 were detected with Allele-specific polymerase chain reaction (ASA-PCR) and di-allele-specific-amplification with artificially modified primer (diASA-AMP)...
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