Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptome analysis reveals human cytomegalovirus reprograms monocyte differentiation toward an M1 macrophage.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2008

Chan Gary, Bivins-Smith Elizabeth R, Smith M Shane, Smith Patrick M, Yurochko Andrew D

Abstract excerpt

Monocytes are primary targets for human CMV (HCMV) infection and are proposed to be responsible for hematogenous dissemination of the virus. Monocytes acquire different functional traits during polarization to the classical proinflammatory M1 macrophage or the alternative antiinflammatory M2 macrophage. We hypothesized that HCMV induced a proinflammatory M1 macrophage following infection to promote viral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion
Share to Cell Adhesion Molecules

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytomegalovirus

Share to Macrophages

Share to Monocytes

Share to Phosphatidic Acids

Share to Up-Regulation

Share to Uridine

Source

Open in PubMed Open full text

Identifiers

PMID: 18566437
DOI: 10.4049/jimmunol.181.1.698
PMCID: PMC2614917

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptome analysis reveals human cytomegalovirus reprograms monocyte differentiation toward an M1 macrophage.PMID 18566437Read ↗

Human cytomegalovirus induction of a unique signalsome during viral entry into monocytes mediates distinct functional changes: a strategy for viral disseminationSemantic proximity Read ↗

HCMV Reprogramming of Infected Monocyte Survival and Differentiation: A Goldilocks PhenomenonSemantic proximity Read ↗

Human Cytomegalovirus Induces Monocyte Differentiation and Migration as a Strategy for Dissemination and PersistenceSemantic proximity Read ↗

Modulation of Monocyte Effector Functions and Gene Expression by Human Cytomegalovirus InfectionSemantic proximity Read ↗

Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene ExpressionSemantic proximity Read ↗

The molecular principles governing HCMV infection outcomeSemantic proximity Read ↗

Human Cytomegalovirus Interleukin-10 Polarizes Monocytes toward a Deactivated M2c Phenotype To Repress Host Immune ResponsesSemantic proximity Read ↗

Monocytes and Macrophages as Viral Targets and ReservoirsSemantic proximity Read ↗

Transcriptome Analysis of NF-κB- and Phosphatidylinositol 3-Kinase-Regulated Genes in Human Cytomegalovirus-Infected MonocytesSemantic proximity Read ↗

Transcriptomic Profiling of the Development of the Inflammatory Response in Human Monocytes In VitroSemantic proximity Read ↗

Virus-associated Inflammation Imprints an Inflammatory Profile on Long-lived Monocyte-derived Macrophages in the Human LiverSemantic proximity Read ↗

Persistent Inflammation and Non-AIDS Comorbidities During ART: Coming of the Age of MonocytesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.