Article
A randomized study of clofarabine versus clofarabine plus low-dose cytarabine as front-line therapy for patients aged 60 years and older with acute myeloid leukemia and high-risk myelodysplastic syndrome.
Blood - 1 Sept 2008
Faderl Stefan, Ravandi Farhad, Huang Xuelin, Garcia-Manero Guillermo, Ferrajoli Alessandra, Estrov Zeev, Borthakur Gautam, Verstovsek Srdan, Thomas Deborah A, Kwari Monica, Kantarjian Hagop M
Abstract excerpt
We previously reported the feasibility of clofarabine and cytarabine combinations in AML. Questions remain as to (1) the therapeutic advantage of this combination and (2) the role of lower doses of clofarabine and cytarabine in older patients. We have conducted an adaptively randomized study of l...
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