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Molecular determinants of ammonia and urea conductance in plant aquaporin homologs.

FEBS letters - 9 Jul 2008

Dynowski Marek, Mayer Maria, Moran Oscar, Ludewig Uwe

Abstract excerpt

Aquaporins and/or aquaglyceroporins regulate the permeability of plant membranes to water and small, uncharged molecules. Using molecular simulations with a plant plasma membrane aquaporin tetramer, the residues in the channel constriction region were identified as the crucial determinants of ammonia and urea conductance. The impact of these residues was experimentally verified using AtPIP2;1 pore mutants....

Topics

Ammonia
Aquaporins
Arabidopsis Proteins
Biological Transport
Computer Simulation
Electric Conductivity
Membrane Proteins
Models, Molecular
Mutation
Plant Proteins
Urea

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PMID: 18565332
DOI: 10.1016/j.febslet.2008.06.012

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