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Article

Diagnostic criteria for the Zappella variant of Rett syndrome (the preserved speech variant).

Brain & development - 1 Mar 2009

Renieri A, Mari F, Mencarelli M A, Scala E, Ariani F, Longo I, Meloni I, Cevenini G, Pini G, Hayek G, Zappella M

Abstract excerpt

The preserved speech variant is the milder form of Rett syndrome: affected girls show the same stages of this condition and by the second half of the first decade are making slow progress in manual and verbal abilities. They walk without help, and may be able to make simple drawings and write a few words. Most of them can speak in sentences. Autistic behavior can often be observed. We previously described several...

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Source

Identifiers

PMID: 18562141
DOI: 10.1016/j.braindev.2008.04.007

Genes

MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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