Article
Addressing the challenges of a cross-national investigation: lessons from the Pittsburgh-Pisa study of treatment-relevant phenotypes of unipolar depression.
Clinical trials (London, England) - 1 Jan 2008
Frank Ellen, Cassano Giovanni B, Rucci Paola, Fagiolini Andrea, Maggi Luca, Kraemer Helena C, Kupfer David J, Pollock Bruce, Bies Robert, Nimgaonkar Vishwajit, Pilkonis Paul, Shear M Katherine, Thompson Wesley K, Grochocinski Victoria J, Scocco Paolo, Buttenfield Joan, Forgione Rocco Nicola
Abstract excerpt
BACKGROUND: To date, no cross-national RCT has addressed the mechanisms underlying the relative success of pharmacological and psychotherapeutic interventions for depression. A multi-site clinical trial that includes psychotherapy as one of the treatments presents numerous challenges related to cross-site consistency and communication. PURPOSE: This report describes how those challenges were met in the study...
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