Article
The regulation of PTC containing transcripts of the human NDUFS4 gene of complex I of respiratory chain and the impact of pathological mutations.
Biochimie - 1 Oct 2008
Panelli Damiano, Petruzzella Vittoria, Vitale Rita, De Rasmo Domenico, Munnich Arnold, Rötig Agnès, Papa Sergio
Abstract excerpt
The regulation of alternative transcripts of the NDUFS4 gene of complex I of the respiratory chain has been studied in human cell lines. One of the alternative transcripts (SV1) is subjected to the NMD degradation pathway which involves the hUPF1 and hUPF2 factors. Another transcript (SV3) appears to be controlled in the nuclear fraction and to be enhanced when hUPF1 is depleted, but unaffected by translation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.