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EspC translocation into epithelial cells by enteropathogenicEscherichia colirequires a concerted participation of type V and III secretion systems

10 Jun 2008

Abstract excerpt

EspC is a non-locus of enterocyte effacement (LEE)-encoded autotransporter protein secreted by enteropathogenic Escherichia coli (EPEC) that causes a cytopathic effect on epithelial cells, including cytoskeletal damage. EspC cytotoxicity depends on its internalization and functional serine protease motif. Here we show that during EPEC infection, EspC is secreted from the bacteria by the type V secretion system...

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PMID: 18547338
DOI: 10.1111/j.1462-5822.2008.01181.x

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