Has HIV evolved to induce immune pathogenesis?

doi:10.1016/j.it.2008.04.005

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Article

Has HIV evolved to induce immune pathogenesis?

Trends in immunology - 1 Jul 2008

Bartha István, Simon Péter, Müller Viktor

Abstract excerpt

Human immunodeficiency virus (HIV) induces a chronic generalized activation of the immune system, which plays an important role in the pathogenesis of AIDS. This ability of the virus might either be an evolved (adaptive) trait or a coincidental side effect of jumping to a new host species. We argue that selection favours the ability of HIV to induce immune activation at the local sites of infection (e.g. lymph...

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