Article
Adiponectin levels and genotype: a potential regulator of life span in humans.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 May 2008
Atzmon Gil, Pollin Toni I, Crandall Jill, Tanner Keith, Schechter Clyde B, Scherer Philipp E, Rincon Marielisa, Siegel Glenn, Katz Micol, Lipton Richard B, Shuldiner Alan R, Barzilai Nir
Abstract excerpt
Although caloric restriction in numerous models extends life, longevity in humans is suggested to be limited by the increased prevalence of obesity. Adiponectin, a fat-derived peptide, has a protective role against age-related disease, and thus is an excellent candidate gene for longevity. We studied adiponectin levels in centenarians (n = 118), their offspring (n = 228), and unrelated participants <95 (n = 78)....
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