Article
Exploiting orthologue diversity for systematic detection of gain-of-function phenotypes.
BMC genomics - 29 May 2008
Martelli Maria Luisa, Isella Claudio, Mira Alessia, Fu Limin, Cantarella Daniela, Medico Enzo
Abstract excerpt
BACKGROUND: Systematic search for genes whose gain-of-function by exogenous expression confers an advantage in cell-based selective screenings is a powerful method for unbiased functional exploration of the genome, and has the potential to disclose new targets for cancer therapy. A major limit of this approach resides in the labor-intensive cloning of resistant cells, identification of the integrated genes and...
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