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Article

Could a defective epithelial sodium channel lead to bronchiectasis.

Respiratory research - 28 May 2008

Fajac Isabelle, Viel Marion, Sublemontier Sébastien, Hubert Dominique, Bienvenu Thierry

Abstract excerpt

BACKGROUND: Bronchiectasis is defined as a permanent dilation of the airways arising from chronic bronchial inflammation/infection. In 50% of cases, no etiology can be identified. Recently, the role of the epithelial sodium channel ENaC has been pointed out in the pathophysiology of cystic fibrosis, a disease due to mutations in the CFTR gene and causing bronchiectasis in the airways. Moreover, it was found that...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epithelial Sodium Channels

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Share to Mutation, Missense

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Source

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Identifiers

PMID: 18507830
DOI: 10.1186/1465-9921-9-46
PMCID: PMC2435537

Genes

CFTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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