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Article

ENaCbeta and gamma genes as modifier genes in cystic fibrosis.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Jan 2008

Viel Marion, Leroy Chrystel, Hubert Dominique, Fajac Isabelle, Bienvenu Thierry

Abstract excerpt

BACKGROUND: Clinical phenotype varies among cystic fibrosis (CF) patients with identical CF transmembrane conductance regulator (CFTR)genotype, suggesting that genetic modifiers exist. Transgenic mice that overexpress SCNN1beta present CF-like lung disease symptoms. Mutations or variants in SCNN1beta may therefore potentially modulate the clinical phenotype in CF patients. METHODS: We analysed by DHPLC SCNN1beta...

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Share to Cystic Fibrosis
Share to Cystic Fibrosis Transmembrane Conductance Regulator

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial Sodium Channels

Share to Forced Expiratory Volume

Share to Genetic Heterogeneity

Share to Mutation, Missense

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Source

Identifiers

PMID: 17560176
DOI: 10.1016/j.jcf.2007.04.003

Genes

CFTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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