Article
Cognitive functioning and survival in the elderly: the SSADH C538T polymorphism.
Annals of human genetics - 1 Sept 2008
De Rango F, Leone O, Dato S, Novelletto A, Bruni A C, Berardelli M, Mari V, Feraco E, Passarino G, De Benedictis G
Abstract excerpt
The variability of the Succinic Semialdehyde Dehydrogenase (SSADH, or ALDH5A1) gene affects both pathological and normal phenotypes correlated to cognitive function. We tested the association between the C538T polymorphism of the SSADH gene and preservation of cognitive function in the elderly, and its possible effects on survival. A sample from southern Italy (514 subjects; 18-107 years) was screened for C538T...
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