Article
Resistance to Ca2+-induced opening of the permeability transition pore differs in mitochondria from glycolytic and oxidative muscles.
American journal of physiology. Regulatory, integrative and comparative physiology - 1 Aug 2008
Picard Martin, Csukly Kristina, Robillard Marie-Eve, Godin Richard, Ascah Alexis, Bourcier-Lucas Céline, Burelle Yan
Abstract excerpt
This study determined whether susceptibility to opening of the permeability transition pore (PTP) varies according to muscle phenotype represented by the slow oxidative soleus (Sol) and superficial white gastrocnemius (WG). Threshold for Ca2+-induced mitochondrial Ca2+ release following PTP opening was determined with a novel approach using permeabilized ghost myofibers. Threshold values for PTP opening were...
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