Article
Small cell carcinoma: arising in Lynch syndrome: a previously undocumented occurrence.
International journal of surgical pathology - 1 Feb 2009
Oman Sarah A, Ballinger Lori, Cerilli Lisa A
Abstract excerpt
Lynch syndrome is a genetic cancer predisposition syndrome caused by an inherited defect in 1 of 4 DNA mismatch repair genes (mutL homolog 1, mutS homolog 2, mutS homolog 6, and postmeiotic segregation 2). Despite the theoretically increased risk in all tissues, Lynch syndrome exhibits tissue specificity, with a particular tendency among affected individuals to develop colorectal and endometrial cancer at a young...
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