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Article

Analysis of the Escherichia coli nusA10(Cs) allele: relating nucleotide changes to phenotypes.

Journal of bacteriology - 1 Feb 1991

Craven M G, Friedman D I

Abstract excerpt

The Escherichia coli nusA gene product, known to influence transcription elongation, is essential for both bacterial viability and growth of lambdoid phages. We report the cloning and sequencing of the conditionally lethal nusA10(Cs) allele. Changes from nusA+ were observed at nucleotides 311 and 634. Functional studies showed that both nucleotide changes are necessary for the cold-sensitive phenotype, although...

Topics

Amino Acid Sequence
Bacterial Proteins
Base Sequence
Cell Division
Cloning, Molecular
Escherichia coli
Molecular Sequence Data
Phenotype
Plasmids
Restriction Mapping
Transcription Factors

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Identifiers

PMID: 1847364
DOI: 10.1128/jb.173.4.1485-1491.1991
PMCID: PMC207286

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1847364-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Analysis of the Escherichia coli nusA10(Cs) allele: relating nucleotide changes to phenotypes.PMID 1847364Read ↗

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