Article
Copper deficiency myelopathy and subacute combined degeneration of the cord - why is the phenotype so similar?
Medical hypotheses - 1 Aug 2008
Winston Gavin P, Jaiser Stephan R
Abstract excerpt
Copper deficiency myelopathy (CDM) is an increasingly recognised mimic of subacute combined degeneration (SCD) of the cord due to cobalamin (vitamin B(12)) deficiency. It has been suggested that copper deficiency induces myelopathy through dysfunction of cytochrome oxidase, which is known to be copper-dependent. However, cytochrome oxidase is not cobalamin-dependent, so this hypothesis fails to explain the...
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