Article
The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination.
Nature medicine - 1 Jun 2008
Chiarle Roberto, Martinengo Cinzia, Mastini Cristina, Ambrogio Chiara, D'Escamard Valentina, Forni Guido, Inghirami Giorgio
Abstract excerpt
An ideal vaccination strategy against tumors relies on specific antigens that are required for tumor maintenance. For lymphoma, vaccination with subject-specific immunoglobulin idiotypes has had the most promising results. Here we show that DNA vaccination with plasmids encoding portions of the cytoplasmic domain of anaplastic lymphoma kinase (ALK), which has been translocated in different fusion proteins...
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