Article
Role of cMET expression in non-small-cell lung cancer patients treated with EGFR tyrosine kinase inhibitors.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Sept 2008
Zucali P A, Ruiz M G, Giovannetti E, Destro A, Varella-Garcia M, Floor K, Ceresoli G L, Rodriguez J A, Garassino I, Comoglio P, Roncalli M, Santoro A, Giaccone G
Abstract excerpt
BACKGROUND: Approximately 10% of unselected non-small-cell lung cancer (NSCLC) patients responded to the epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) treatment. However, resistance mechanisms are not well understood. We evaluated several potential biological markers of intrinsic EGFR-TKIs-resistance in NSCLC. MATERIALS AND METHODS: pAKT, pERK, cSRC, E-cadherin, cMET[pY1003],...
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