Article
Role of glutathione s-transferase polymorphisms and chronic allograft dysfunction.
Transplantation proceedings - 1 Apr 2008
Pagliuso R G, Abbud-Filho M, Alvarenga M P S, Ferreira-Baptista M A S, Biselli J M, Biselli P M, Goloni-Bertollo E M, Pavarino-Bertelli E C
Abstract excerpt
Polymorphisms within genes encoding glutathione S-transferases (GSTs) may affect responses against damage induced by oxidative stress and therefore play a role to prevent chronic allograft dysfunction (CAD). In the present study, we estimated the frequencies of GSTM1- and GSTT1-null genotypes among 227 renal transplant recipients seeking to establish an association with CAD. Patients persistently displaying serum...
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