Use of human androgen receptor gene analysis to aid the diagnosis of JMML in female noonan syndrome patients.

Abstract excerpt

Noonan syndrome (NS) patients are at increased risk for developing juvenile myelomonocytic leukemia (JMML), an aggressive clonal disorder of aberrant cell proliferation. Many NS patients exhibit spontaneously remitting monocytosis and transient myeloproliferation. The distinction between bone mar...

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