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Article

Association between polymorphisms in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) on chromosome 8p and schizophrenia.

Neuropsychobiology - 1 Jan 2008

Lohoff Falk W, Weller Andrew E, Bloch Paul J, Buono Russell J, Doyle Glenn A, Ferraro Thomas N, Berrettini Wade H

Abstract excerpt

Linkage studies have suggested a susceptibility locus for schizophrenia (SZ) exists on chromosome 8p21-22. The vesicular monoamine transporter 1 gene (VMAT1), also known as SLC18A1, maps to this SZ susceptibility locus. Vesicular monoamine transporters are involved in the presynaptic vesicular packaging of monoamine neurotransmitters, which have been postulated to play a role in the etiology of SZ. Variations in...

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PMID: 18451639
DOI: 10.1159/000129668

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