Article
Decellularized, xenogeneic small-diameter arteries: transition from a muscular to an elastic phenotype in vivo.
Journal of biomedical materials research. Part B, Applied biomaterials - 1 Oct 2008
Bergmeister Helga, Plasenzotti Roberto, Walter Ingrid, Plass Christian, Bastian Fabienne, Rieder Erwin, Sipos Wolfgang, Kaider Alexandra, Losert Udo, Weigel Guenter
Abstract excerpt
Reports regarding the biocompatibility of xenogeneic, decellularized bioprosthetic implants differ between bioinertness and complete graft degradation. We investigated heparin-crosslinked and nonheparinized, xenogeneic vascular substitutes in a rat model. Porcine arteries (15 x 1.5 mm) were decellularized by multistep detergent and enzymatic techniques, which were followed by heparin-crosslinking in 50% of the...
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