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Article

Unusually rapid evolution of Neuroligin-4 in mice.

Proceedings of the National Academy of Sciences of the United States of America - 29 Apr 2008

Bolliger Marc F, Pei Jimin, Maxeiner Stephan, Boucard Antony A, Grishin Nick V, Südhof Thomas C

Abstract excerpt

Neuroligins (NLs) are postsynaptic cell-adhesion molecules that are implicated in humans in autism spectrum disorders because the genes encoding NL3 and NL4 are mutated in rare cases of familial autism. NLs are highly conserved evolutionarily, except that no NL4 was detected in the currently available mouse genome sequence assemblies. We now demonstrate that mice express a distant NL4 variant that rapidly evolved...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18434543
DOI: 10.1073/pnas.0801383105
PMCID: PMC2359808

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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