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Article

TLR6 Modulates First Trimester Trophoblast Responses to Peptidoglycan

1 May 2008

Abstract excerpt

Intrauterine bacterial infections are a well-established cause of pregnancy complications. One key observation in a number of abnormal pregnancies is that placental apoptosis is significantly elevated. First trimester trophoblast cells are known to express TLR1 and TLR2 and to undergo apoptosis following exposure to Gram-positive bacterial peptidoglycan (PDG). Thus, the objectives of this study were to determine...

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PMID: 18424724
DOI: 10.4049/jimmunol.180.9.6035

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