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Article

Immunohistochemical analysis supports a role for INI1/SMARCB1 in hereditary forms of schwannomas, but not in solitary, sporadic schwannomas.

Brain pathology (Zurich, Switzerland) - 1 Oct 2008

Patil Sushama, Perry Arie, Maccollin Mia, Dong Shumin, Betensky Rebecca A, Yeh Tu-Hsueh, Gutmann David H, Stemmer-Rachamimov Anat O

Abstract excerpt

The INI1/SMARCB1 protein product (INI1), a component of a transcription complex, was recently implicated in the pathogenesis of schwannomas in two members of a single family with familial schwannomatosis. Tumors were found to have both constitutional and somatic mutations of the SMARCB1 gene and showed a mosaic pattern of loss of INI1 expression by immunohistochemistry, suggesting a tumor composition of mixed...

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Share to Chromosomal Proteins, Non-Histone
Share to Diagnosis, Differential

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Immunohistochemistry

Share to Neoplasms, Second Primary

Share to Neurilemmoma

Share to Neurofibromin 2

Share to SMARCB1 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 18422762
DOI: 10.1111/j.1750-3639.2008.00155.x
PMCID: PMC2743242

Genes

SMARCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Immunohistochemical analysis supports a role for INI1/SMARCB1 in hereditary forms of schwannomas, but not in solitary, sporadic schwannomas.PMID 18422762Read ↗

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