Article
Slowly progressive spinocerebellar ataxia with extrapyramidal signs and mild cognitive impairment (SCA21).
Cerebellum (London, England) - 1 Jan 2008
Delplanque J, Devos D, Vuillaume I, De Becdelievre A, Vangelder E, Maurage C A, Dujardin K, Destée A, Sablonnière B
Abstract excerpt
Spinocerebellar ataxia 21 is a slowly progressive and mild ataxia associated with extrapyramidal signs. Affected subjects exhibit a moderate gait and limb ataxia variably associated with akinesia, tremor, rigidity, hyporeflexia, and mild cognitive impairment. The responsible gene has been assigned to a 19 Mbases interval on chromosome 7p in a single French family. No evidence of significant linkage to this locus...
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