Article
Rapid eye movement sleep disturbances in Huntington disease.
Archives of neurology - 1 Apr 2008
Arnulf Isabelle, Nielsen Jørgen, Lohmann Ebba, Schiefer Johannes, Schieffer Johannes, Wild Edward, Jennum Poul, Konofal Eric, Walker Matthew, Oudiette Delphine, Tabrizi Sarah, Durr Alexandra
Abstract excerpt
BACKGROUND: Sleep disorders including insomnia, movements during sleep, and daytime sleepiness are common but poorly studied in Huntington disease (HD). OBJECTIVE: To evaluate the HD sleep-wake phenotype (including abnormal motor activity during sleep) in patients with various HD stages and the length of CAG repeats. Because a mild hypocretin deficiency has been found in the brains of some patients with HD...
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