Article
Relationship between kdr mutation and resistance to pyrethroid and DDT insecticides in natural populations of Anopheles gambiae.
Journal of medical entomology - 1 Mar 2008
Reimer Lisa, Fondjo Etienne, Patchoké Salomon, Diallo Brehima, Lee Yoosook, Ng Arash, Ndjemai Hamadou M, Atangana Jean, Traore Sekou F, Lanzaro Gregory, Cornel Anthony J
Abstract excerpt
The spread of insecticide resistance genes in Anopheles gambiae Giles sensu stricto threatens to compromise vector-based malaria control programs. Two mutations at the same locus in the voltage-gated sodium channel gene are known to confer knockdown resistance (kdr) to pyrethroids and DDT. Kdr-e involves a leucine-serine substitution, and it was until recently thought to be restricted to East Africa, whereas...
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