Article
Distribution of knock-down resistance mutations in Anopheles gambiae molecular forms in west and west-central Africa.
Malaria journal - 29 Apr 2008
Santolamazza Federica, Calzetta Maria, Etang Josiane, Barrese Elena, Dia Ibrahima, Caccone Adalgisa, Donnelly Martin J, Petrarca Vincenzo, Simard Frederic, Pinto Joao, della Torre Alessandra
Abstract excerpt
BACKGROUND: Knock-down resistance (kdr) to DDT and pyrethroids in the major Afrotropical vector species, Anopheles gambiae sensu stricto, is associated with two alternative point mutations at amino acid position 1014 of the voltage-gated sodium channel gene, resulting in either a leucine-phenylalanine (L1014F), or a leucine-serine (L1014S) substitution. In An. gambiae S-form populations, the former mutation...
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