Article
Papillon-Lefèvre syndrome and malignant melanoma. A high incidence of melanoma development in Japanese palmoplantar keratoderma patients.
Dermatology (Basel, Switzerland) - 1 Jan 2008
Nakajima Koji, Nakano Hajime, Takiyoshi Noriko, Rokunohe Akiko, Ikenaga Satsuki, Aizu Takayuki, Kaneko Takahide, Mitsuhashi Yoshihiko, Sawamura Daisuke
Abstract excerpt
Papillon-Lefèvre syndrome (PLS) is a rare autosomal-recessive genodermatosis characterized by palmoplantar hyperkeratosis and severe early-onset periodontitis. The development of malignant cutaneous neoplasms within the hyperkeratotic lesions of the syndrome is quite rare. Here, we report on a 51-year-old Japanese woman with PLS associated with recurrent malignant melanoma (MM). Mutation analysis of the cathepsin...
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