Article
BEHAB/brevican requires ADAMTS-mediated proteolytic cleavage to promote glioma invasion.
Journal of neuro-oncology - 1 Jul 2008
Viapiano Mariano Sebastian, Hockfield Susan, Matthews Russell Thomas
Abstract excerpt
Malignant gliomas are the most common and deadly primary brain tumors, due to their infiltrative invasion of the normal neural tissue that makes them virtually impossible to completely eliminate. We have previously identified and characterized the proteoglycan BEHAB/brevican in gliomas and have demonstrated that upregulation and cleavage of this CNS-specific molecule promote glioma invasion. Here, we have further...
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