Article
Late onset in dysferlinopathy widens the clinical spectrum.
Neuromuscular disorders : NMD - 1 Apr 2008
Klinge L, Dean A F, Kress W, Dixon P, Charlton R, Müller J S, Anderson L V, Straub V, Barresi R, Lochmüller H, Bushby K
Abstract excerpt
LGMD2B, Miyoshi Myopathy and Distal Anterior Compartment Myopathy are caused by mutations in the dysferlin gene (DYSF) leading to progressive muscular weakness and wasting with onset usually within the second or third decade of life. We here present a patient with disease onset at 73 years. The presenting symptom was exercise-induced stiffness of the trunk and proximal leg muscles without major progression over a...
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