Article
Gene-environment association of an ITGB2 sequence variant with obesity in ethnic Japanese.
Obesity (Silver Spring, Md.) - 1 Jun 2008
Awaya Tomokazu, Yokosaki Yasuyuki, Yamane Kiminori, Usui Hiroshi, Kohno Nobuoki, Eboshida Akira
Abstract excerpt
Mice lacking the integrin alphaMbeta2 (Mac-1, CD11b/CD18) develop an obese phenotype on western diet rich in fat. However, no association has been found between variations in the human genes encoding the integrin alphaMbeta2 and obesity. This study was aimed to investigate the association between a single-nucleotide polymorphism (SNP) (rs235326) in the gene encoding human integrin beta2 subunit (ITGB2) with...
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