A single residue mutation of 5-enoylpyruvylshikimate-3-phosphate synthase in Pseudomonas stutzeri enhances resistance to the herbicide glyphosate.

doi:10.1007/s10529-008-9703-8

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Article

A single residue mutation of 5-enoylpyruvylshikimate-3-phosphate synthase in Pseudomonas stutzeri enhances resistance to the herbicide glyphosate.

Biotechnology letters - 1 Aug 2008

Liang Aimin, Sha Jiying, Lu Wei, Chen Ming, Li Liang, Jin Dan, Yan Yongliang, Wang Jin, Ping Shuzhen, Zhang Wei, Wang Yiding, Lin Min

Abstract excerpt

A novel class II 5-enoylpyruvylshikimate-3-phosphate synthase (EPSPS) was identified from Pseudomonas stutzeri A1501 by complementation of an Escherichia coli auxotrophic aroA mutant. The single amino acid substitution of serine (Ser) for asparagine (Asn)-130 of the A1501 EPSPS enhanced resistance to 200 mM glyphosate. The mutated EPSPS had a 2.5-fold increase for IC(50) [glyphosate] value, a 2-fold increase for...

Read the complete abstract on PubMed

Topics

3-Phosphoshikimate 1-Carboxyvinyltransferase
Amino Acid Substitution
Genes, Bacterial
Glycine
Herbicide Resistance

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Herbicides

Kinetics

Mutant Proteins

Mutation

Phylogeny

Pseudomonas stutzeri

Glyphosate

Source

Open in PubMed

Identifiers

PMID: 18368293
DOI: 10.1007/s10529-008-9703-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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