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Article

Significant immunomodulatory effects of <i>Pseudomonas aeruginosa</i> quorum-sensing signal molecules: possible link in human sepsis

9 May 2008

Abstract excerpt

Pathogenic bacteria use quorum-sensing signal molecules to co-ordinate the expression of virulence genes. Animal-based studies have demonstrated the immunomodulatory effects of quorum-sensing signal molecules. In the present study, we have examined the impact of these molecules on normal human immune function in vitro and compared this with immune changes in patients with sepsis where quorum-sensing signal...

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PMID: 18363571
DOI: 10.1042/cs20080018

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