Article
Identification of a novel HLA-B allele, HLA-B*5529, by haplotype-specific sequencing.
Tissue antigens - 1 May 2008
Emmerich F, Schönemann C, Galicki L, Salama A
Abstract excerpt
We have identified a novel HLA-B allele, B*5529. The novel allele differs from HLA-B*5501 by a single nucleotide substitution at codon 479 in exon 3 resulting in an amino acid change from alanine to valine. This alteration neither affects the peptide binding site nor the T-cell receptor (TCR) contact residues. Thus, the newly found allele is estimated to have a low alloreactive potential in case of a mismatch to...
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